St. John's Wort Guide

St. John’s wort is an herbal ingredient used to support healthy mood balance and help with nervousness, restlessness, and related sleep problems. Learn when it may be relevant to your health goals and what to know before choosing a supplement.

✅ Reviewed by Jamieson's Science Team

Quick Answers

What is St. John’s wort used for?

St. John’s wort is used in herbal medicine to support healthy mood balance and help relieve nervousness and restlessness.¹

Can St. John’s wort support mood?

Yes. Health Canada recognizes standardized St. John’s wort extracts for helping promote healthy mood balance.¹

Can St. John’s wort help with sleep?

It can help relieve sleep disturbances associated with mood imbalance, and Jamieson also positions its current formula for restlessness and insomnia.¹

Does St. John’s wort interact with medications?

Yes. St. John’s wort has important interactions with many medications, including antidepressants, birth control, blood thinners, and some heart, cancer, and immune-system medications.

What is St. John’s wort?

St. John’s wort, or Hypericum perforatum, is an herb whose flowering tops are used in natural health supplements. Health Canada recognizes it for mood, nervousness, restlessness, and related sleep support.¹

Its naturally occurring compounds include hypericin and hyperforin. Standardized supplements measure these compounds so each serving provides a consistent amount.

How does St. John’s wort support the body?

St. John’s wort is used to help support healthy mood balance and calm restlessness and nervous tension. For someone whose stress or mood is also interfering with sleep, Health Canada recognizes it for helping relieve sleep disturbances associated with mood imbalance.¹

That makes it most relevant when the goal isn’t simply “more energy” or “better sleep,” but rather supporting the connection between mood, feeling settled, and being able to rest.

Which health goals can St. John’s wort support?

Mood Support

St. John’s wort can help promote healthy mood balance, making it relevant when emotional well-being is the primary goal.¹

Stress Support

St. John’s wort is traditionally used to help relieve nervousness and restlessness, which may help when it’s difficult to feel calm or settled.¹

Sleep Support

St. John’s wort can help relieve sleep disturbances associated with mood imbalance, while Jamieson also positions its formula for insomnia and restlessness.¹

How can St. John’s wort fit into your routine?

St. John’s wort may be relevant when mood, nervous tension, and sleep are affecting each other.

If you’re feeling restless or tense: It’s traditionally used to help relieve nervousness and restlessness.¹
If mood is the main concern: Standardized St. John’s wort extracts are used to support healthy mood balance.¹
If mood is disrupting sleep: It may help with sleep disturbances connected to mood imbalance.¹
Give it time: Jamieson advises using its product for at least one week to see beneficial effects rather than expecting an immediate result.

*It is important to consult your trusted healthcare practitioner before adding any new natural health supplement to your routine.

What should you look for in a St. John’s wort supplement?

Start with your health goal, then check the extract strength, standardization, and medication warnings carefully.

Look for Hypericum perforatum: This is the medicinal form of St. John’s wort.¹
Check for standardization: Hypericin and hyperforin levels help show consistency between servings.¹
Compare extract strength: Jamieson provides 200 mg of a 5:1 extract, equal to 1,000 mg of raw herb.
Check active compounds: Jamieson is standardized to 0.3% hypericin and 3% hyperforin.
Match it to your goal: Look for licensed claims around mood, nervousness, restlessness, or sleep support.
Check every medication you use: St. John’s wort has unusually important drug interactions and can make some medications less effective.
Look for an NPN: Choose a licensed Canadian natural health product.

For more than 100 years, Jamieson has combined scientific expertise with rigorous quality testing. Every product is backed by the Jamieson 360 Quality Promise.

*It is important to consult your trusted healthcare practitioner before adding any new natural health supplement to your routine.

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FAQs

What health goals is St. John’s wort most relevant for?

St. John’s wort is most relevant when the goal is healthy mood balance, reducing nervousness or restlessness, or addressing sleep disturbances associated with mood imbalance.¹

What are hypericin and hyperforin?

Hypericin and hyperforin are naturally occurring compounds in St. John’s wort. Standardized extracts specify how much they contain so consumers can compare the consistency and strength of different formulas. Health Canada’s monograph uses standardized hypericin and/or hyperforin levels for mood and related sleep claims.

How much St. John’s wort is in Jamieson Neurosome St. John’s Wort?

Each tablet contains 200 mg of a 5:1 extract, equivalent to 1,000 mg of raw St. John’s wort herb, standardized to 0.3% hypericin and 3% hyperforin.

Sources

1. Health Canada. St. John’s Wort — Hypericum perforatum Oral Monograph. Natural and Non-prescription Health Products Directorate. Updated July 26, 2024.[Text Wrapping Break]https://webprod.hc-sc.gc.ca/nhpid-bdipsn/dbImages/mono_st-johns-wort--oral_english.pdf

2. Health Canada. Natural Health Products Ingredients Database — Hypericum perforatum.[Text Wrapping Break]https://webprod.hc-sc.gc.ca/nhpid-bdipsn/ingredReq?id=6208